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Anim Reprod Sci
It typically affects the hands and feet, is mild to moderate in intensity, and does not require dose reduction in most cases
A patient who was in a calorie deficit at 220 pounds may be at maintenance at 196 pounds eating exactly the same way
Simultaneously, saliva, digestive enzymes, insulin, and other substances are secreted to prepare food intake (21)
Pediatric weight management programs typically require baseline laboratory testing (glucose, liver function, kidney function, lipid panel) and may include imaging to screen for nonalcoholic fatty liver disease before starting treatment
Overall, the use of metformin as an adjunct treatment for AN, particularly in patients with underlying hyperglycemia, is supported in the literature, but further studies are needed to clarify dosing, duration of therapy, and patient populations that will benefit most from adding metformin to their treatment regimens
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