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The pending EVOKE and EVOKE Plus trials of daily oral semaglutide participants aged 5585 years with mild cognitive impairment or mild dementia due to Alzheimers disease with confirmed amyloid abnormalities by PET scan or cerebrospinal fluid biomarkers The only difference in the 2 trials is with respect to entry criteria with EVOKE Plus that allows for small vessel pathology

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Semaglutide is contraindicated in patients with personal or family history of medullary thyroid carcinoma or Multiple Endocrine Neoplasia syndrome type 2, though the relevance to humans remains uncertain

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A 2023 analysis found that newer weight loss medications can blunt some of the appetite signals that usually bring progress to a halt, which may help extend the period of active weight loss to around 24 months before seeing a plateau

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