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In SURMOUNT-1, 72 weeks of tirzepatide induced mean WL of 1622.5% in people without diabetes compared to 2.4% with placebo, with no sign of the weight plateauing, suggesting that there may be further WL with long-term use [46]
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The Phase 2 trial used 4-week intervals between increases, and groups that followed dose escalation had better tolerability than those started at fixed higher doses
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