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Am J Physiol Endocrinol Metab 2020;318:E956E964

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After the plasma membrane carrier-mediated GSH release from the cell, GSH becomes accessible to the active site of - glutamyl transpeptidase, which catalyzes the breakdown of the GSH - glutamyl bond forming two fractions: The -glutamyl fraction and the cysteinyl-glycine by transferring the -glutamyl fraction to an amino acid acceptor, forming -glutamyl-amino acid

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Oxidative stress, a condition resulting from an imbalance between free radicals and antioxidants in the body, can lead to cellular damage and is linked to various health issues, including aging and chronic diseases

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According to lead author Michael Corley, PhD, associate professor at UC San Diego School of Medicine and the Stein Institute for Research on Aging, semaglutide appeared to counter some of those effects

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An amino acid derivative that plays a crucial role in the body's energy production

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