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Additionally, it is believed that the PPG neurons are not the only source of GLP-1 in the brain, as gut-derived GLP-1 has been implicated in satiety studies to exert its effects on the brain as well [52]

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Tirzepatide has three critical improvements over first-generation GLP1RAs

A more complete plateau, when the scale essentially stops moving, typically arrives between 12 and 18 months for most patients, though a small proportion will continue losing weight for up to two years

Access to licensed clinicians who can screen you for contraindications and manage your side effects