For RFS, the survival probability was 93.4% with insulin/metformin and 97.4% with GLP-1RAs at both five and 10 years
6A and C)
With regard to adhesion, resting, unstimulated primary T cells reportedly do not show significant binding to integrin ligands whereas certain Jurkat cell lines already show a high ligand-binding state, at least for the integrin ligand VCAM-1 54
This situation feels different from other drug classes because it is: diabetes and obesity are massive markets, and beyond the FDA approved indicated populations, theres a swath of people interested in getting their hands on GLP-1 agonists off-label to help them lose a few extra pounds
And the culprit, more often than anyone wants to admit, is a reconstitution error made in the very first five minutes of handling the peptide
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