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Many individuals begin noticing secondary symptoms, such as cramping or pressure, that make daily tasks difficult to focus on

Changes in Lean Body Mass With Glucagon-Like Peptide-1-Based Therapies and Mitigation Strategies

The most common: constipation appears in the first 1 to 2 weeks after a dose step and improves over the next 2 to 4 weeks as the gut adapts

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Do not delay treatment pending confirmatory tests if neurological involvement is suspected

Dose-dependent increases in heart rate were also observed, consistent with the glucagon receptor agonism component of the drug, and this warrants careful monitoring in individuals with pre-existing cardiac conditions