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NHE3 phosphorylation at serines 552 and 605 does not directly affect NHE3 activity

2020;383:1413-1424 Anker SD, et al

When you stop treatments, benefits slowly fade

However, safety can vary depending on individual health conditions and interactions with other medications

For example, one theory is that the decrease of estrogen in aging women, blood flow to the connect tissue decreases and lower circulation results in lower collagen production

Park G, Jeon SJ, Ko IO, Park JH, Lee KC, Kim MS, et al