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When the body is at a lower weight, and you are no longer on the medication, your brain and body prioritize storing fat and see the decrease in calories as a sign of distress, which can mean you may still gain weight even if you continue habits you began while on medication, such as eating smaller portions

Increased energy and appetite suppressed

doi: 10.1101/2023.06.22.546075 [DOI] [PMC free article] [PubMed] [Google Scholar] 66.Sun F, Zhou J, Dai B, Qian T, Zeng J, Li X, et al

In terms of valence (pleasure) and arousal (motivation), GLP-1 lowers the arousal or urgency triggered by food cues while boosting the positive valence of actually eating the food, thereby signaling the brain, "This is enough, youre full." These neuroimaging findings give a concrete mechanism for the subjective reports of reduced cravings on GLP-1 therapy

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Lahousse, L