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doi: 10.3390/cells10030571 302 WilliamsJ

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Retinol and Antioxidant Combinations: A formulation combining retinol (0.5%), bakuchiol, Ophiopogon japonicus root extract, vitamin C (30%), vitamin E, and ubiquinone (coenzyme Q10) showed significant clinical improvement in women with mild-to-moderate facial hyperpigmentation [207]

In a human study published that same year, Khavinson and colleagues observed that elderly human subjects who received epithalamin treatment for two to three years experienced a 1.6-1.8 fold decreased mortality rate compared with a control group

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