Notably, melatonin enhanced the fusion of mitochondria by activating adenosine monophosphate activated protein kinase (AMPK) to stabilize Opa1 in myocardial ischemia/reperfusion injury (Zhang et al., 2019)
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Some individuals, particularly those with severe obesity or conditions such as type 2 diabetes, chronic kidney disease or heart disease, may benefit from longer-term treatment
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