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In SURMOUNT-1 , a 72-week Phase 3 double-blind trial in 2,539 adults with obesity (or overweight with a complication) but without diabetes, once-weekly tirzepatide produced mean weight changes of 15.0% (5 mg), 19.5% (10 mg), and 20.9% (15 mg) versus 3.1% with placebo, with 5057% of participants on the higher doses losing at least 20% of body weight

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Patients should also be aware that Arkansas state law prohibits sending patients home with clinic-prepared, prefilled injectable syringes

Saline is sometimes preferred when a compound is sensitive to the benzyl alcohol preservative in bacteriostatic water, or when an isotonic solution is specifically called for