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It seems the antioxidant effect of edaravone on plasma is stronger in treatment group than in prevention group, which might due to the sudden increase in the antioxidant defense mechanisms overcoming a prolonged inhibitory oxidative effect in the short-term application of edaravone [45]

They do not, on their own, demonstrate clinical benefit in people that is the job of the human trials discussed later in this article

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51 , 691697, doi:10.1210/jcem-51-4-691 (1980)