Aging (Albany NY) (2019) 11(2):53648
Whether compounded or brand-name, tirzepatide (GLP-1 + GIP) consistently produces greater weight loss than semaglutide alone, but it comes at a higher monthly price point throughout all providers compared
Amylin, released with insulin from beta cells in the pancreas, induces its satiating effect via both the homoeostatic and hedonic regions of the brain
ArGLP-1 also reduced total mortality (HR 0.88, 95% CI 0.820.94, p = 0.0001) and hospital admission due to heart failure (HR 0.89, 95% CI 0.820.98, p = 0.013), all without increasing the risk of severe hypoglycemia, pancreatic problems or retinopathy.87 A recent post hoc analysis of CVOT with semaglutide has shown a gain in time free of cardiovascular disease of 1.7 years in those patients with CKD vs
Insulin Feedback: The insulin secreted by -cells acts as a negative feedback signal to further inhibit glucagon release from -cells (Zheng et al., 2024)
It makes it more informed, which is exactly where good treatment decisions start
