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Higher doses might make these gastrointestinal effects more likely or more severe

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Sublingual delivery bypasses first-pass liver metabolism, potentially improving bioavailability compared to swallowed oral forms, though it still does not match injectable absorption rates

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DIGAMI (Diabetes Mellitus, Insulin Glucose Infusion in Acute Myocardial Infarction) Study Group

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Staying hydrated is important, as fluids keep the mouth moist and reduce irritation

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Analysis of the national multicenter study (1976 to 1985) N Engl J Med

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Vitamin Therapy has been administered for over a century

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