Damiri F, et al
Based on this neuronal projection distribution, downstream brainstem nuclei appear to regulate portion size, given their reception of vagal and circulating hormonal afferents, and can modulate food intake, digestion, and absorption (117)
This change means that, for the majority of patients, compounded semaglutide will no longer be a viable option moving forward
Writing the original draft, editing, methodology, and proofreading: DS
The SURMOUNT-2 trial, which investigated tirzepatide for obesity treatment in people with type 2 diabetes, reported a mean body weight reduction of 12.8% and 14.7% for weekly doses of 10 and 15 mg, respectively, after 72 weeks (53)
Broader melanocortin receptor profile than selective MC1R agonists, with both peripheral pigmentation and central appetite/sexual function effects