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Factors that are specific to the individual and influence the selection of treatment encompass personalized blood sugar targets (101), the persons susceptibility to hypoglycemia, and their medical history or risk factors associated with cardiovascular, renal, hepatic, and other comorbidities and complications related to diabetes (102104)

10.1016/j.bbrc.2013.12.109 89

Biology of GLP-1 and current uses Derived from the post-translational modification of proglucagon peptide, GLP-1 is a neuroendocrine peptide hormone known as an incretin

Some clients describe temporary sensations such as warmth, pressure or mild discomfort at the injection site

Another GoF variant, A316T, shows a 2-fold increase in cAMP accumulation ( 2+ mobilization (which is essential for insulin secretion)

What research developments are needed to advance clinical use of these peptides