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"Tirzepatide, a dual GIP/GLP-1 receptor co-agonist for the treatment of type 2 diabetes." Cardiovascular Diabetology, 2022

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Consequently, the activation of RAS transcription triggers the downstream activation of two distinct yet interconnected pathways such as the PI3K-AKT signaling pathway and the RAFMEKERK pathway

Cagrilintide represents the modern re-engineering of that idea: a lipidated, structurally modified amylin analogue stable enough for once-weekly dosing and active at both the amylin and calcitonin receptors

The cases herein, to our knowledge, are the first to demonstrate potential mental health benefits of tirzepatide, a GLP-1/GIP receptor agonist