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PLOS ONE 9:e94530

Wright and Harding, 2019)

This is based on studies involving TB-500 overexpression lentiviral vector in transfecting umbilical vein endothelial cells (HUVEC) and murine critical limb ischemia (CLI) models

The 10-day window is intended to deliver a concentrated signaling effect to the cells involved in circadian regulation and renewal before the long rest allows those adaptations to consolidate

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Severe vitamin deficiency in this case is rare