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Wnt/-catenin signaling is necessary for HF initiation (Andl et al., 2002

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Upon receptor binding, it initiates Gq-coupled intracellular signaling, thus activating phospholipase C, generating inositol trisphosphate, and mobilizing intracellular calcium

[12] Animal reproduction studies have not demonstrated teratogenicity, and historical clinical use suggests low embryotoxic risk when lidocaine is administered at recommended dosages