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In this location, the transporter is exposed to the external environment, and then, to bacteria (Rotoli et al., 2020)

Skin changes appear after 48 weeks

Steder M, Alla V, Meier C, Spitschak A, Pahnke J, Frst K, et al

ECM-based biomarkers reflecting MMP-9 activity, such as C3M (MMP-9 mediated degradation of type III collagen) and C4M (MP-2, 9, 12 mediated degradation of type IV collagen), are significantly elevated in Hurley stages II and III of HS and show a moderate-strong correlation with the IHS score, indicating their utility in assessing disease activity and severity [104] (Table 1, Fig

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