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Finally, long-term treatment for bipolar disorder is strongly recommended, but guidelines do not recommend the use of antidepressants as a maintenance treatment [12, 32]

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Targeting metabolic vulnerabilities in specific macrophage subsets, such as limiting ferroportin-mediated iron export in M2 TAMs or enhancing ACSL4-dependent lipid peroxidation in inflammatory TAMs, may shift the TME toward a ferroptosis-permissive state

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