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"More frequent monitoring might be appropriate if you're losing weight rapidly, eating very little, experiencing significant fatigue, hair loss or treating a known deficiency," says Pratt

This subjective improvement could reflect placebo effect, improved overall nutritional status from paying more attention to diet, natural adaptation to the medication over time, or actual b12 repletion if deficiency existed

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The differences between groups were calculated by Wilcoxon rank sum test (non-parametric statistics)

However, it is not known whether these mechanisms are direct, central actions of SGLT-2is may be one of the essential links to the clinical improvement of RAAS and sympathetic activation in cardiovascular conditions like chronic heart failure in T2D