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Mattioli : One of our core findings is that obesity is associated with primary dysbiosisreduced microbiota diversity and an increased presence of bacteria that extract more energy from food, leading to visceral fat accumulation and chronic inflammation

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Most clinical trials used once-weekly dosing without specifying a preferred time, suggesting flexibility exists within standard protocols

Combined with reduced food intake from appetite suppression, these metabolic shifts create an ideal environment for headache formation

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