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At doses of 25 to 100 grams, IV vitamin C achieves plasma concentrations 100 to 500 times higher than those possible through oral administration

Detection of podocyte loss in patients with proteinuria points to podocyte resilience as a potential treatment target and the use of calcineurin inhibitors to reduce proteinuria in patients with lupus nephritis 40,115

This is the same principle behind why recombinant protein biologics (monoclonal antibodies, insulin analogues) are never shaken: air-water interfacial agitation unfolds polypeptide chains that then reassemble into non-native oligomers or fibrils

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