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16,18,19,20,21,22 As cystine influx through the cystineglutamate xCT antiporter occurs concomitantly with glutamate efflux, increased cystine import can also be related to poor prognosis

sanfranciscensis were found to be several folds higher for cells supplemented with GSH as compared to cysteine supplemented cells and control culture [80]

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Disclosure The authors declare that they have no competing interests

doi:10.5604/17322693.1208033 26

While several E3 ligases were found in complex with NHR-49::GFP in vivo under fasted conditions 42 , we chose the top two interactors to screen: the WW domain-containing E3 ligase, WWP-1, and HECT domain E3 ligase, HECD-1