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Diabetes Obes Metab 26(Suppl 4):1627 Xiang J, Qin L, Zhong J, Xia N, Liang Y (2023) GLP-1RA liraglutide and semaglutide improves Obesity-Induced muscle atrophy via SIRT1 pathway

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Clinical applications in cardiovascular disease prevention Recent American College of Cardiology/American Heart Association guidelines advocate for the use of GLP-1RAs in patients with T2DM at high risk of atherosclerotic cardiovascular disease (ASCVD), irrespective of well-controlled glucose levels, based on the clinical trials mandated by FDA-issued industry guidelines in December 2008 to assess the cardiovascular effects of new diabetic therapies (247)

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Safety & Contraindications While Retatrutide shows promise, it is a potent biological agent

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