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doi: 10.1002/ana.10440

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They highlight that inadvertent intravascular injection, high cumulative dosing, and patient factors (extremes of age, cardiac, hepatic, or renal disease, pregnancy) are major contributors, and that bupivacaine carries the greatest cardiotoxic risk

Similarly, NPY through activation of its Y1 receptor, was demonstrated to be critical for the development of allergic airway inflammation in mice [178]