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The metabolism of APAP has been well-studied and the distributions of its metabolites in the plasma and urine of humans are well-documented[4, 6, 7], as are the hepatic values in mice and rats[8]

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Traditional capsules often show bioavailability in the 2 to 10 percent range, meaning only a small fraction may reach circulation

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These mechanisms can be classified under two main functional categories: (a) upregulation of the sense gene through direct interactions with the sense gene mRNA transcript, and (b) upregulation of the sense gene through ASO-mediated inhibition of the NAT