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Pipeline data was extracted from diverse sources including pharmaceutical databases, clinical trial registries, scientific literature and funders grant databases following our pipeline methodology

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This variability points to personalized factors rather than a universal medication effect

Of note is that in CF an intrinsic downregulation of the antioxidant response regulator and NF-B antagonist Nuclear Factor Erythroid 2-related factor 2 (Nrf2) is described (Moliteo et al., 2022)

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