When appetite decreases, fluid intake often decreases alongside it because much of our daily hydration comes from food
In animal studies, GLP-1 receptor agonists have been associated with thyroid C-cell tumours, though this finding has not been established in humans
Review By HARMINDER HARMY KAUR Last Updated On : Mar 13 2026 BSc(hons) Pharmacy GPhC Number: 2061107 Authored By GURDEV SEHMI Last Reviewed On : Mar 23 2026 BSc Pharm, MRPharmS, Independent Prescriber, Superintendent Pharmacist, Clinical Lead GPhC Number: 2050925
Accordingly, moderate lean tissue decline observed during GLP-1RA-induced weight loss could be interpreted as a physiological component of body composition change rather than evidence of pathological sarcopenia, unless accompanied by functional deterioration
However, in the late 20th century, scientists discovered the "Incretin Effect." They noticed that oral glucose triggered a much higher insulin response than intravenous glucose
For lasting weight loss results, it is recommended to adopt a holistic approach that includes both medication and lifestyle changes
