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The selective mechanism is particularly valuable because it avoids the collateral damage to healthy cells that occurs with cytotoxic chemotherapy approaches to senescent cell elimination

Primarily from soy and soy products, isoflavones have been shown to improve arterial stiffness, TC, TG, LDL-C, HDL-C, fasting glucose, glucose homeostasis and HOMA-IR (Reference Glisic, Kastrati and Gonzalez-Jaramillo45Reference Tokede, Onabanjo and Yansane47)

Targeting central and peripheral peptidergic systems, such as the central nervous system and the gastrointestinal tract, offers opportunities but also presents several challenges for clinical application and efficacy

Peptide therapies are considered elective wellness treatments and are typically not covered by insurance

in control mice (A, C) and experimental mice (B, D)

Infliximab is a chimeric anti-TNF- monoclonal antibody specifically binding to both soluble and membrane-bound TNF (91, 92)