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Skin changes depend on individual factors such as baseline pigmentation, lifestyle, sun exposure, diet, and consistency of use

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Published in the New England Journal of Medicine in 2025, this Phase 3 study enrolled 610 Chinese adults with obesity or overweight accompanied by at least one weight-related comorbidity

The recommendations are nonbinding, and final FDA action is still pending as of July 25, 2026

They are indicated for type 2 diabetes management, weight reduction in obesity, and cardiovascular risk reduction, with ongoing investigation into metabolic dysfunction-associated steatohepatitis, chronic kidney disease, and heart failure with preserved ejection fraction