Some researchers have shown that metformin activates AMPK and triggers the downstream GSH system to slow DOX-mediated oxidative impairment in the myocardium [225, 226]
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It accounts for approximately 4050% of the total body mass, and it can easily withstand different stimuli from exercise-induced mechanical stress and metabolic stress to other environmental stimuli, including heat exposure and nutrient availability (Rivas and Fielding, 2012
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Glutathione, a master antioxidant naturally found in the body, plays a critical role in combating free radicals and reducing oxidative stress