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The AUGUSTUS trial (N=4,614) showed that adding aspirin to apixaban in patients with atrial fibrillation and recent acute coronary syndrome increased bleeding events from 7.3% to 10.9% over 6 months (HR 1.89 to 95% CI 1.59 to 2.24) [12]

Bioavailability varies significantly depending on preparation, presence of the activating enzyme, heat exposure, and individual gut and metabolic differences

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Patients interested in next-generation GLP-1 therapies should focus on building a strong metabolic foundation with currently available options in the meantime