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The intermediate is subsequently transported into synaptic vesicles via the vesicular monoamine transporter (VMAT) and hydroxylated by dopaminehydroxylase (DBH) to yield methylnorepinephrine ( panel 2 )

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For instance, the p.N409S mutation, commonly found in European and Ashkenazi Jewish populations, is linked to a less severe PD phenotype, while the p.L483P mutation is associated with a more aggressive form of PD

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