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In this setting as well, treatments with antioxidant substances could be appropriate, but literature data indicate that antioxidants alone are unable to induce significant clinical changes, except perhaps in mild forms, and must be used in conjunction with standard drug treatments to achieve measurable results (124)

Figure 2 Oxidative Phosphorylation in Inflammatory Effector Cells The major metabolic abnormality of RA CD4 + T cells lies in the mitochondria ( Figure 3 )

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