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R.IqubalA.et al (2022)

The expression of NRF1 is highest in skeletal muscle which is also the tissue that accounts for the largest percentage of glucose disposal in the body and, therefore, is the tissue that is most responsible for the hyperglycemia resulting from impaired insulin signaling

Most clinical guidelines recommend baseline labs and periodic monitoring

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doi:10.1016/S0021-9258(18)82452-8