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What the Discontinuation Data Actually Shows The STEP 1 trial extension the largest and most cited study on what happens after stopping semaglutide followed participants for one year after they ceased treatment

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Risinger said the launch of Novo's pill has benefited from the fact that the company is leveraging the Wegovy brand name, which is recognizable by many patients, and immediately launched direct-to-consumer advertising for the product in early January

In people with obesity, that adds up to serious, sustained weight loss around 15% of body weight on average with semaglutide, and up to 17% with tirzepatide

AE-driven discontinuation rose with dose, consistent with the dose-dependent gastrointestinal profile of the GLP-1 class

Many experts suggest that a "dual-action" approach is most effective