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Shop Medications , Manufacturer Recommendations Eli Lilly advises that when you start tirzepatide or after any dose escalation, you should: Continue your oral contraceptive Add a barrier method (for example, condoms) for 4 weeks Or switch to a nonoral method (IUD, vaginal ring, implant) before starting tirzepatide if you prefer not to use a barrier method How Tirzepatide Affects Oral Contraceptives Tirzepatide is a dual agonist of GLP-1 and GIP receptors