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Before taking GLP-1s, many of the weight-loss-drug improvisers I interviewed said they devoted an inordinate amount of mental energy to their weight

All currently approved injectable GLP-1RAs have demonstrated CV safety (non-inferiority) in CVOTs [12, 19,20,21,22,23], but only four have demonstrated both CV safety and superiority relative to standard of care [12, 20, 22, 23]

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doi: 10.1172/jci.insight.173205 12 DiricanO.KayginP.OguztznS.HusseiniA

Therefore, it is plausible that thyroid hormones can upregulate HO-1 expression via ROS signaling