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Anti-cancer treatments often target damage generated by oxidative stress, especially lipid peroxidation

10.1016/j.addr.2020.02.006 56 FrankD

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In this study, as amino acid precursors could be fed to improve concentrations of intracellular free l-cysteine, we resorted to overexpression of GK instead of loss-of-function mutations in GPR for accumulation of -glutamyl phosphate to strengthen the redirection of -glutamyl phosphate to GSH synthesis

doi:10.1055/a-0653-7108 [26] Schnedl WJ, Lackner S, Enko D, Schenk M, Mangge H, Holasek SJ

Free radicals can cause premature aging by damaging the skin's cells and accelerating the breakdown of collagen and elastin