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The oral tirzepatide offered through MadeMed is a compounded sublingual format

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The injectable version allows for a higher, more consistent dose of semaglutide over the course of the treatment, leading to greater reductions in body weight

Acta Pharmacol Sin (2021) 43(5):115666

However, some patients may experience symptomatic low blood pressure, particularly when combined with antihypertensive medications, during significant weight loss, or when dehydrated from gastrointestinal side effects