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In the context of diabetes models, it may contribute to heart attack, impaired wound healing, stroke, and kidney damage

score 2: partly confluent or incomplete infarcts (2030% of the area affected)

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RNA sequencing and pathway enrichment analysis show FOXO4-DRI significantly downregulates extracellular matrix-receptor interaction pathways, including fibronectin (Fn1), tenascin C (Tnc), and thrombospondin 2 (Thbs2), all critical components of fibrotic tissue architecture

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