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Neuron 79(3):416438

Glutathione, the most abundant non-protein thiol in the brain, plays a crucial role in the antioxidant defense system, protecting neurons from oxidative damage

This mechanism supports cellular resilience by upregulating endogenous antioxidants, including heme oxygenase-1 (HO-1), thus reducing oxidative stress, preventing mitochondrial dysfunction, and limiting apoptosis [11, 20, 23, 41, 42]

Pavone B, Bucci S, Sirolli V, Merlini G, Del Boccio P, Di Rienzo M, et al