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This suggests that knocking out CUL5 in human CD8 + CAR T cells similarly enhances CAR signaling activity, IFN- secretion, and tumor cell clearance capability (22)

DOI: 10.1111/j.1365-2036.2008.03870.x

GLP-1 medications, by comparison, cost $800$1,200 per month, adding up to $10,000+ yearly, making surgery more cost-effective long-term