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As a cofactor, cobalamins are essential for two cellular reactions: the mitochondrial methylmalonyl-CoA mutase conversion of methylmalonic acid (MMA) to succinate, which links lipid and carbohydrate metabolism, and the activation of methionine synthase, which is the rate-limiting step in the synthesis of methionine from homocysteine and 5-methyltetrahydrofolate

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The two are native forms, and are superior to hydroxo B12 or cyano B12

Subdued light conditions were as well commonly required by previous cyanidation-based methods [12,13,14, 19] considering the photo-liability of cobalamins

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