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Immunohistochemical analysis also revealed a significant decrease in the hepatic expression of both proapoptotic markers Bax and caspase-3 with significant increase in antiapoptotic Bcl-2 expression in rats treated with NTZ-200, NAC or 4-PBA when compared to MTX group (Figure 9)

The first spectrum captured reflects spectral perturbation consistent with the binding of NADPH adjacent to the flavin without evidence of NADPH oxidation or flavin reduction

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