Mechanistically, spexin signals primarily through galanin receptor subtypes GALR2 and GALR3, receptors with complex roles in nociception, mood regulation, and metabolic control
Glycolysis and oxidative phosphorylation, which break down glucose into the form of ATP to produce energy, is the main source of energy for the brain
And the anecdotal evidence supports this reasoning
GLP-1 receptor agonists and cancer risk in adults with obesity: A new chapter in metabolic oncology
NAD-related protocols (not a peptide but often grouped with them): Cellular energy and cognitive support
However, it is important to distinguish between evidence-based medical treatments like tirzepatide and dietary supplements, which are not regulated as pharmaceuticals and lack the same level of clinical validation