Overall, the selected trials had a low to moderate risk of bias
Rothberg, MD, a clinical professor at the University of Michigan, specializing in treating overweight and obesity
(They studied participants who did not have diabetes because the disease introduces more confounding variables.) The researchers suspected that people with the PAM variant would have lower levels of GLP-1 in their blood, perhaps because the unamidated form would be less stable
Injectable formulations benefit from site rotation to minimize local reactions
Clinicians should exercise caution in patients with a history of pancreatitis or gastroparesis, inflammatory bowel disease, other gut motility disorders, medullary thyroid carcinoma, or Multiple Endocrine Neoplasia syndrome type 2, and pause therapy when clinically indicated, such as before anesthesia
Participants with the variants did not respond differently to other common diabetes treatments, including sulfonylureas, metformin and DPP-4i
